Arginine is a vitally important amino acid that has been studied for more than fifty years. Amino acids are the building blocks of protein, and protein is the building block of all living cells. The study of amino acids is making a major contribution to the understanding of diseases. Amino acid therapies have been used successfully to prevent aging, prevent heart disease, enhance memory, eliminate depression, control stress, improve sleep, relieve arthritis, reduce herpes, arrest alcoholism, manage allergies, and promote hair growth.
Most researchers recommend the free (also called undigested) forms of amino acids, which do not need to be digested and are absorbed directly into the blood for distribution throughout the body. In hospital settings, arginine may be prescribed for therapeutic purposes in the forms of di-peptides, tri-peptides, or hydrolysates, but generally the free form is considered best, particularly the L-form.
Deficiency produces symptoms of muscle weakness, similar to muscular dystrophy. Arginine-deficiency impairs insulin production, glucose production, and liver lipid metabolism. Conditional deficiencies of arginine are associated with the presence of excessive ammonia in the blood, excessive lysine, rapid growth, pregnancy, trauma, or protein deficiency and malnutrition. Arginine deficiency is also associated with rash, hair loss and hair breakage, poor wound healing, constipation, fatty liver, hepatic cirrhosis, and hepatic coma.
To achieve greatest effectiveness as a human growth hormone releaser, L-arginine should be consumed on an empty stomach at bedtime. HGH release occurs 30-60 minutes after falling asleep, and also during and just following vigorous exercise.
The therapeutic usages of L-Arginine include:
Arthritis. Found in high concentrations in the connective tissues, arginine is a component of collagen that plays a vital role in the production of new tissue and bone cells.
Alzheimer's Patients. Arginine may prove helpful in treating Alzheimer's, because it raises polyamine levels.
Cancer Patients. Arginine retards tumor growth by enhancing immune function. Arginine increases the size and activity of the thymus gland, which produces T-cells. Large doses of arginine can lower polyamines, which are present in various cancers in elevated levels. Arginine has been found to inhibit the growth of several types of tumors in laboratory mice.
Liver Disorders. Arginine aids in liver detoxification by neutralizing ammonia, and may benefit in the treatment of liver disorders such as liver injury, hepatic cirrhosis, and fatty liver degeneration.
Weight Loss. Arginine facilitates a reduction in body fat, while increasing lean muscle mass. Arginine inhibits the absorption of dietary fat.
Body Building. More than fifty research studies reportedly support the value of arginine supplementation for athletes. Arginine is considered to be key to efficient muscle metabolism because of its role in the transport, storage, and elimination of nitrogen. Creatine is derived from arginine, as are guanidophosphate and phosphoarginine, all of which have roles in muscle metabolism.
After a vigorous workout, the body has increased testosterone and HGH production for a period lasting approximately two hours. During this timeframe, dietary arginine can contribute to a hormonal environment that produces increased protein synthesis and muscle growth.
Fertility. Seminal fluid contains substantial quantities of arginine, and arginine may be beneficial in treating sterility in men. In one study, men with low sperm counts took 4 grams of arginine orally, with 80% of the men showing significant improvement, in some cases resulting in pregnancies. Arginine is also noted by one researcher for its ability to increase libido and induce erections. Arginine and aspartic acid have been shown to have a positive effect on sperm viability and motility.
Inherited Urea Cycle Disorders (Rare). Arginine therapy is employed in the treatment of arginemia, citrullinemia, and argininosuccinic aciduria.
Anti-Aging Considerations
Arginine is involved in the production of variety of enzymes and hormones. Arginine facilitates the release of HGH, stimulates the pancreas for insulin production, and is a component in the hormone vasopressin produced by the pituitary gland. One mechanism for arginine as an HGH releaser may be its capacity for blocking secretion of the HGH-inhibitor: somatostatin.
Arginine is essential for optimum growth and in the regulation of protein metabolism. The main source of energy for muscle and other cells is glucose, but glucose metabolism produces ammonia, which is toxic unless rapidly converted to another compound. The primary metabolic role of arginine is in stimulating the enzyme that starts the urea cycle, which converts ammonia into a less toxic compound called urea that the blood carries to the kidneys for excretion.
As a cholesterol fighter, a high ratio of arginine-to-lysine is recommended. In the urea cycle, citrulline is a precursor of arginine, so it may be that foods rich in citrulline (onions, scallions, garlic) lower cholesterol because the citrulline is converted to arginine in the body.
As a booster of the immune system, arginine stimulates the thymus and promotes lymphocyte production. This may be the key to arginine's ability to promote healing of burns and other wounds. During stress (good or bad), the thymus gland typically shrinks, and sickness results; however, arginine facilitates the maintenance of the gland's proper size and normal production of lymphocytes.
In support of brain function, arginine is believed to serve as a precursor to nitric oxide (NO), a neurotransmitter. Nitric oxide plays a role in the dilation and constriction of small blood vessels in brain. Therefore, arginine may have a positive effect on cerebral circulation. Arginine pyroglutamate is cited for having cognitive-enhancing effects.
L-arginine is one of the most powerful tools in any anti-aging program because of its functional value in promoting the production of HGH and other hormones, strengthening the immune system, improving lean muscle mass and reducing fat, regulating several vital metabolic processes, improving cholesterol profiles, supporting brain function, and enhancing sexuality.
This supplement is not for individuals suffering from an established coronary artery disease or myocardial infraction. People with glaucoma or herpes simplex should avoid this supplement.
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